Episode 1: The Ghost | Aired: September 20th, 2016 | Runtime: 43 Minutes

In light of the Sokovia Accords, and with Hydra obliterated, S.H.I.E.L.D. has been legitimatized again and no longer needs to operate in the shadows. Since the world presumes that Coulson is dead, the organization needed a new Director to be the face of the organization. Coulson finds himself back in the role as an agent and teamed with Mack, and together they are tasked with tracking down and confirming the presence of Enhanced people, aka Inhumans. Agent May is tasked with training specialist strike teams, and Fitz and Simmons have taken a big step forward in their relationship.

Episode 2: Meet the New Boss | Aired: September 27th, 2016 | Runtime: 43 Minutes

Following Coulson's stepping down as Director, Jeffrey Mace is made the new Director of S.H.I.E.L.D. and its public face. Daisy meets with Robbie at his place of work, saying she knows about his history but is surprised to find he isn't Inhuman like her. May's exposure from the specter last episode gets out of hand where Mace, revealing he's a super strong Inhuman, knocks her out and sends her to an undisclosed location. Mack & Fitz investigate the specter and encounter Ghost Rider. The specter who infected May releases her compatriots who were in similar containers for years due to using the "Darkhold".

Episode 3: Uprising | Aired: October 11th, 2016 | Runtime: 42 Minutes

Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman Registration worldwide. Simmons and Dr. Radcliffe have only a short time to save May before she succumbs to her illness.

Episode 4: Let Me Stand Next to Your Fire | Aired: October 18th, 2016 | Runtime: 43 Minutes

As Ghost Rider’s quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D.. Coulson and Mack must rely on an unlikely ally in their time of desperate need. Daisy reunites with a familiar face to stop the Watchdogs.

Episode 5: Lockup | Aired: October 25th, 2016 | Runtime: 42 Minutes

As Robbie Reyes struggles to control The Ghost Rider, S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.

Episode 6: The Good Samaritan | Aired: November 2nd, 2016 | Runtime: 41 Minutes

The shocking origin story of Robbie's transition into Ghost Rider is revealed as the lives of Coulson and the team hang in the balance.

Episode 7: Deals With Our Devils | Aired: November 29th, 2016 | Runtime: 43 Minutes

After losing half their team, the remaining members look for answers as time begins to run out for Ghost Rider.

Episode 8: The Laws of Inferno Dynamics | Aired: December 6th, 2016 | Runtime: 42 Minutes

S.H.I.E.L.D. and Ghost Rider find themselves unlikely allies when the lives of all of Los Angeles hang in the balance.

Episode 9: Broken Promises | Aired: January 10th, 2017 | Runtime: 43 Minutes

Coulson is unaware of a dark secret May is hiding, even as the two grow closer. Aida is determined to find the Darkhold.

Episode 10: The Patriot | Aired: January 17th, 2017 | Runtime: 42 Minutes

Coulson and Mack discover a shocking secret about Mace, which leaves all of S.H.I.E.L.D. in a dangerous position.

Episode 11: Wake Up | Aired: January 24th, 2017 | Runtime: 42 Minutes

May races to find the truth about what happened to her, while Aida’s next move could mean the death of them all.

Episode 12: Hot Potato Soup | Aired: January 31st, 2017 | Runtime: 42 Minutes

Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Coulson and the team can save them before the clock ticks out.

Episode 13: BOOM | Aired: February 7th, 2017| Runtime: 43 Minutes

Daisy, Mace, and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Coulson and Mack come face-to-face with Radcliffe’s inspiration for Aida.

Episode 14: The Man Behind the Shield | Aired: February 14th, 2017 | Runtime: 42 Minutes

Mace fights for his life while Coulson and team find themselves in a deadly cat-and-mouse game as they attempt his rescue.

Episode 15: Self Control | Aired: February 21st, 2017 | Runtime: 43 Minutes

As more LMDs infiltrate S.H.I.E.L.D., suspicion begins to turn to paranoia among the members of Coulson's team.

Episode 16: What If... | Aired: April 4th, 2017 | Runtime: 42 Minutes

Hail the New World Order! Daisy and Simmons are the only hope to save everyone in a world controlled by Hydra.

Episode 17: Identity and Change | Aired: April 11th, 2017 | Runtime: 43 Minutes

As Daisy and Simmons struggle to discover an escape route to the real world, the identity of the Inhuman leader of the Resistance is revealed.

Episode 18: No Regrets | Aired: April 18th, 2017 | Runtime: 43 Minutes

The truth behind Fitz’s turn could bring down all of S.H.I.E.L.D.

Episode 19: All the Madame's Men | Aired: April 25th, 2017 | Runtime: 42 Minutes

Daisy finds herself teamed up with an unlikely partner. Meanwhile, Aida prepares to put her ultimate end game into effect.

Episode 20: Farewell, Cruel World! | Aired: May 2nd, 2017 | Runtime: 41 Minutes

Daisy and Simmons race against the clock to get the team out of the Framework, but not everyone is ready to leave.

Episode 21: The Return | Aired: May 9th, 2017 | Runtime: 43 Minutes

Coulson and the team's victory in the Framework is short-lived, revealing an even deadlier enemy looming against them all.

Episode 22: World's End | Aired: May 16th, 2017 | Runtime: 43 Minutes

With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.